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牛效迪
发布人:官方|首頁|太阳集团2018登录网址  发布时间:2016-04-06   浏览次数:


  

牛效迪,吉林大学官方|首頁|太阳集团2018登录网址教授,博士生导师。主要研究方向:(1) 抗真菌食源性天然保鲜剂筛选及作用机制研究;(2) 抗食源性病原菌药物设计、食品安全检测及分子药理学等研究。成功建立天然化合物抗菌作用靶标及分子作用机制的分析和验证平台。

先后承担参与国家自然科学基金重点项目、科技部973项目、国家自然科学基金面上项目、博士后面上和特别资助等多项国家级项目,累计科研经费超过400万元。以第一责任作者身份在国际知名期刊The Journal of Infectious DiseasesEuropean Journal of Pharmaceutical SciencesFood ControlEuropean Journal of Medicinal ChemistryMolecular PharmacologyPLoS Computational Biology等发表学术论文60余篇。

学术任职:

吉林省食品学会理事。

教育经历

19982002 东北师范大学化学学院,获学士学位。

20022005 东北师范大学化学学院,获硕士学位。

20052008 中国科学院长春应用化学研究所,获博士学位。

工作经历:

2008~至今 吉林大学官方|首頁|太阳集团2018登录网址,教授,博士生导师。

20092011 军事医学科学院军事兽医研究所,博士后。

20142016 吉林大学动物医学学院,博士后。

20172018 香港浸会大学中医药学院,访问学者。

近五年主持项目:

  1. 国家自然科学基金面上项目,2021.01-2024.12,矢车菊素抑制金葡菌丝氨酸/苏氨酸蛋白磷酸酶(Stp1)分子机制确证及构效关系分析。(项目批准号:32072919)

  2. 国家自然科学基金面上项目,2019.01-2022.12茶黄素抑制Bβ-内酰胺酶的靶点确证及构效关系研究。(项目批准号:31872525)

  3. 国家自然科学基金面上项目,2016.01-2019.12木犀草素抗李斯特菌感染的分子机制。(项目批准号:31572566)

  4. 吉林省科技厅重点科技研发项目,2020.01-2022.12,茶多酚类复合天然保鲜剂对银耳野玫瑰果复合饮料防腐关键技术研究及应用。(项目批准号:20200402060NC)

  5. 吉林省科技厅国际科技合作项目,2019.01-2021.12,熊果酸靶向AMP活化蛋白激酶的抗衰老活性分子机制研究。(项目批准号:20190701032GH)

  6. 国家自然科学基金重点国际(地区)合作项目子课题,2020.01-2021.12,百里香酚靶向SipA分子机制确证及构效关系分析。(项目批准号:31620103918)

  7. 国家自然科学基金重点项目子课题,2012.01-2016.12,溶血素-药物小分子复合物分子动力学模拟。(项目批准号:31130053)

代表性论文:

  1. An antimicrobial agent prepared by N-succinyl chitosan immobilized lysozyme and its application in strawberry preservation, FOOD CONTROL, 108: 106829. (1) (第一责任作者)

  2. Fisetin Inhibits Listeria monocytogenes Virulence by Interfering With the Oligomerization of Listeriolysin O, JOURNAL OF INFECTIOUS DISEASES, 211(9): 1376-1387. (1) (第一责任作者)

  3. Molecular insight into the inhibition mechanism of cyrtominetin to alpha-hemolysin by molecular dynamics simulation, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62: 320-328. (1) (第一责任作者)

  4. Oroxylin A Inhibits Hemolysis via Hindering the Self-Assembly of alpha-Hemolysin Heptameric Transmembrane Pore, PLOS COMPUTATIONAL BIOLOGY, 9(1): e1002869. (1) (第一责任作者)

  5. Effect of amine functionalization of SBA-15 on controlled baicalin drug release, CERAMICS INTERNATIONAL,38(8): 6931-6935. (1) (第一责任作者)

  6. Baicalin Protects Mice From Staphylococcus aureus Pneumonia Via Inhibition of the Cytolytic Activity of alpha-Hemolysin, JOURNAL OF INFECTIOUS DISEASES, 206(2): 292-301. (1) (第一责任作者)

  7. Discovery of the Novel Inhibitor Against New Delhi Metallo-beta-Lactamase Based on Virtual Screening and Molecular Modelling, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(10): 3567. (2) (第一责任作者)

  8. Luteolin Inhibits Listeriolysin O Translation by Directly Targeting the Coding Region of the hly mRNA, FRONTIERS IN MICROBIOLOGY, 10: 1496. (2) (第一责任作者)

  9. Phloretin reduces cell injury and inflammation mediated by Staphylococcus aureus via targeting sortase B and the molecular mechanism, APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 102(24): 10665-10674. (2) (第一责任作者)

  10. Baicalin Weakens Staphylococcus aureus Pathogenicity by Targeting Sortase B, FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY, 8: 418. (2) (第一责任作者)

  11. Insight into the catalytic hydrolysis mechanism of New Delhi metallo-β-lactamase to aztreonam by molecular modeling, JOURNAL OF MOLECULAR LIQUIDS, 282: 244-250. (2) (第一责任作者)

  12. Oligopeptide Targeting Sortase A as Potential Anti-infective Therapy for Staphylococcus aureus, FRONTIERS IN MICROBIOLOGY, 9: 245. (2) (第一责任作者)

  13. Chalcone Attenuates Staphylococcus aureus Virulence by Targeting Sortase A and Alpha-Hemolysin, FRONTIERS IN MICROBIOLOGY, 8: 1715. (2) (第一责任作者)

  14. Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers, MOLECULAR PHARMACOLOGY, 89(3): 376-387. (2) (第一责任作者)

  15. Inhibition of alpha-toxin production by subinhibitory concentrations of naringenin controls Staphylococcus aureus pneumonia, FITOTERAPIA, 86: 92-99. (2) (第一责任作者)

  16. Silibinin In Vitro Protects A549 Cells from Staphylococcus aureus-Mediated Injury and In Vivo Alleviates the Lung Injury of Staphylococcal Pneumonia, PLANTA MEDICA, 79(2): 110-115. (2) (第一责任作者)

  17. Acetyicholinesterase Biosensor Based On Mesoporous Hollow Carbon Spheres/Core-Shell Magnetic Nanoparticles-Modified Electrode for the Detection of Organophosphorus Pesticides, SENSORS, 18(12): 4429. (2) (第一责任作者)

  18. The therapeutic effect of chlorogenic acid against Staphylococcus aureus infection through sortase A inhibition, FRONTIERS IN MICROBIOLOGY, 6: 1031. (2) (第一责任作者)

  19. Design of dipicolinic acid derivatives as New Delhi metallo-beta-lactamase-1 inhibitors using a combined computational approach, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 38: 3384-3395. (3) (第一责任作者)

  20. Electrochemical immunosensor based on an antibody-hierarchical mesoporous SiO2 for the detection of Staphylococcus aureus, RSC ADVANCES, 9(28): 16278-16287. (3) (第一责任作者)

  21. Molecular Modelling reveals the inhibition mechanism and structure-activity relationship of curcumin and its analogues to Staphylococcal aureus Sortase A, JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 37(5): 1220-1230. (3) (第一责任作者)

  22. Insight into the novel inhibition mechanism of apigenin to Pneumolysin by molecular modeling, CHEMICAL PHYSICS LETTERS, 687: 85-90. (3) (第一责任作者)

  23. Investigation of the inhibition effect and mechanism of myricetin to Suilysin by molecular modeling, SCIENTIFIC REPORTS, 7: 11748. (3) (第一责任作者)

  24. Insights into structure and activity of natural compound inhibitors of pneumolysin, SCIENTIFIC REPORTS, 7: 42015. (3) (第一责任作者)

  25. Curcumin protects mice from Staphylococcus aureus pneumonia by interfering with the self-assembly process of alpha-hemolysin, SCIENTIFIC REPORTS, 6: 28254. (3) (第一责任作者)

  26. Beta-sitosterol interacts with pneumolysin to prevent Streptococcus pneumoniae infection, SCIENTIFIC REPORTS, 5: 17668. (3) (第一责任作者)

  27. Quercitrin, an Inhibitor of Sortase A, Interferes with the Adhesion of Staphylococcal aureus, MOLECULES, 20(4): 6533-6543. (3) (第一责任作者)

  28. Novel inhibitor discovery and the conformational analysis of inhibitors of listeriolysin O via protein-ligand modeling, SCIENTIFIC REPORTS, 5: 8864. (3) (第一责任作者)

  29. Molecular Modeling Reveals the Novel Inhibition Mechanism and Binding Mode of Three Natural Compounds to Staphylococcal alpha-Hemolysin, PLOS ONE, 8(11): e80197. (3) (第一责任作者)

  30. Bio-templated synthesis of mesoporous bioactive glass with a hierarchical pore structure, MATERIALS LETTERS, 76: 237-239. (3) (第一责任作者)

  31. Capsaicin Protects Mice from Community-Associated Methicillin-Resistant Staphylococcus aureus Pneumonia, PLOS ONE, 7(3): e33032. (3) (第一责任作者)

  32. Structure-Activity relationship of MDSA and its derivatives against Staphylococcus aureus Ser/Thr phosphatase Stp1, COMPUTATIONAL BIOLOGY AND CHEMISTRY, 85: 107230. (4) (第一责任作者)

  33. Molecular modeling and QM/MM calculation clarify the catalytic mechanism of beta-lactamase N1, JOURNAL OF MOLECULAR MODELING, 25(5): 118. (4) (第一责任作者)

  34. Insight into the inhibition mechanism and structure-activity relationship of 2,6-dipicolinic acid and its analogue to New Delhi metallo-beta-lactamase-1, MOLECULAR SIMULATION, 45(6): 525-531. (4) (第一责任作者)

  35. A Sortase A-Immobilized Mesoporous Hollow Carbon Sphere-Based Biosensor for Detection of Gram-Positive Bacteria, JOURNAL OF ELECTRONIC MATERIALS, 47(7): 4124-4135. (4) (第一责任作者)

  36. Molecular modeling reveals the inhibition mechanism and binding mode of ursolic acid to TLR4-MD2, COMPUTATIONAL AND THEORETICAL CHEMISTRY, 1123: 73-78. (4) (第一责任作者)

  37. Insights into the specific binding site of adenosine to the Stx2, the protein toxin from Escherichia coli O157:H7 using molecular dynamics simulations and free energy calculations, MOLECULAR SIMULATION, 39(3): 199-205. (4) (第一责任作者)

  38. Insight into the dynamic interaction between different flavonoids and bovine serum albumin using molecular dynamics simulations and free energy calculations, JOURNAL OF MOLECULAR MODELING, 19(3): 1039-1047. (4) (第一责任作者)

学术奖励:

  1. 中药成分抗耐药性金黄色葡萄球菌的作用机制及重要靶点,中华人民共和国教育部自然科学二等奖,第三完成人。

授权专利:

  1. 一种N-琥珀酰壳聚糖固载溶菌酶制备抑菌膜的方法, 2019-3-5, 中国, ZL201611072415.5。第一完成人。

联系方式:

联系电话:0431-87836376 (O)

Email: niuxd@jlu.edu.cn; niuxiaodi2006@gmail.com.


 
 
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